The birth of Elizabeth Ann, a black-footed ferret, on December 10, 2020, marked a major achievement in the recovery of the species. Elizabeth Ann is the first black-footed ferret to be cloned with the aim of increasing the genetic diversity of the species. The now 2-month-old ferret was created from frozen cells of a black-footed ferret that lived over three decades ago.

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Black-footed ferrets were once considered extinct, but a family of seven was discovered in 1981. The ferrets were captured to be protected by the Wyoming Game and Fish Department. Having been recovered from only seven ferrets, the current population of the species lacks genetic diversity. The recent cloning is important given that the clone parent, Willa, was recovered from the last wild black-footed ferrets and did not belong to the line of the recovered seven. Samples of the wild ferret were preserved at the San Diego Zoo Global’s Frozen Zoo from 1988.

Related: San Diego Zoo successfully clones an endangered Przewalski’s horse

black-footed ferret poking head out of hole

To improve the species’ resilience to diseases, several organizations have come together. Among the partners involved in the process include the U.S. Fish and Wildlife Service, Revive & Restore, San Diego Zoo Global, ViaGen Pets & Equine and the Association of Zoos and Pets.

“The Service sought the expertise of valued recovery partners to help us explore how we might overcome genetic limitations hampering recovery of the black-footed ferret, and we’re proud to make this announcement today,” said Noreen Walsh, director of USFWS, Mountain-Prairie Region. “Although this research is preliminary, it is the first cloning of a native endangered species in North America, and it provides a promising tool for continued efforts to conserve the black-footed ferret.”

The journey to cloning has been long and with many obstacles, according to Ryan Phelan, executive director of Revive & Restore.

“We’ve come a long way since 2013 when we began the funding, permitting, design, and development of this project with the U.S. Fish and Wildlife Service.” Phelan said. “Genomics revealed the genetic value that Willa could bring to her species.”

According to Walsh, while cloning is one of the ways to improve the genetic diversity of the species, the organizations are also paying attention to habitat-based threats in their efforts to recover the black-footed ferret population.

+ U.S. Fish and Wildlife Service

Images via USFWS