Scientists have linked the spread of the disease breast cancer in mice to a compound that’s in asparagus and several other foods, The Guardian reported. Studies with mice revealed asparagine drives the advance of the cancer, and when researchers reduced asparagine, the amount of “secondary tumors in other tissues” dropped. Cancer Research UK Cambridge Institute director Greg Hannon told The Guardian, “This is a very promising lead and one of the very few instances where there is a scientific rationale for a dietary modification influencing cancer.”
Research with mice showed the amino acid asparagine is important for breast cancer to spread, and scientists think the process could be similar in humans. Researchers found that blocking the amino acid hampered the spread of the cancer. Hannon said in a statement, “It could be that manipulating levels of asparagine in the body might be used as a way to boost a patients’ cancer treatment.”
The researchers blocked asparagine in mice tested, which had an aggressive type of breast cancer, to reduce the cancer’s ability to spread with the drug L-asparaginase. Giving the mice a low-asparagine diet worked to a lesser extent, according to The Guardian.
There’s still a lot work to be done. The Cancer Research UK Cambridge Institute cautioned research is in the early stages and “doesn’t form the basis for DIY diets at home.” This work also doesn’t seem to offer a cure for cancer; per the press release, “So far the story suggests that lowering asparagine levels blunts the ability of cancer cells to spread in mice, but doesn’t affect the original tumor.” Lowering asparagine didn’t prevent breast tumors from forming, the researchers found.
Hannon said, “The difficulty is finding ways to study this in the lab that are relevant to patients. It’s a challenge, but I think it’s worth pursuing.”
The journal Nature published the research online this week. 21 scientists at institutions in the United Kingdom, Canada, and the United States contributed.
Via The Guardian